Protozoa

Etiology: Trichomonas species (muris, minuta, wenyoni) are one celled, eukaryotic organisms.

Incidence: Incidence of trichomonad infection is common.

Transmission:  Transmission is fecal-oral via ingestion of infective cysts.

Distribution:  Giardia muris is found in the anterior small intestine.

Clinical Signs:  Clinical signs are not usually observed. These protozoa may proliferate in diarrheic states, however their role as contributors to disease is poorly defined.

Diagnosis:

Antemortem: Fecal PCR can be used. Wet mounts of fresh fecal material or use of sucrose gradient may reveal cyst forms (this method of diagnosis is difficult).

Postmortem: Wet mounts of cecal contents reveal slow moving, flagellated protozoa with an undulating membrane. Trichomonads move with a jerky, wobbly, undirected motion.

Diagnostic morphology:  Pear- to lemon-shaped trophozoites with an undulating membrane and 3 (tri-) to 4 (tetra-) anterior flagella. There is NO true cyst form.

T. muris 16-26 x 10-14 µm

T. minuta 4-9 x 2-5 µm

T. wenyoni 6-16 x 3-6 µm

Histopathologic examination may also be used to diagnose trichomonad infection.

 

Etiology:  Chilomastix bettencorti is a one celled, eukaryotic organism.

Incidence:  Incidence of infection with Chilomastix bettencorti is common.

Transmission: Fecal-oral transmission via ingestion of infective cysts.

Distribution: Chilomastix bettencorti is found in the cecum and colon.

Clinical signs: Clinical signs are not usually observed. These protozoa may proliferate in diarrheic states, however their role as contributors to disease is poorly defined.

Diagnosis:

Antemortem: Difficult to diagnose antemortem. Wet mounts of fresh fecal material stained with a weak iodine solution may reveal typical lemon-shaped cysts that can be difficult to distinguish from plant material.

Postmortem: Wet mounts of intestinal contents may reveal pear-shaped trophozoites with a spiraling, jerky motion. The spiraling motion will aid in differentiation of Chilomastix trophozoites from trichomonads.

Diagnostic morphology:  Trophozoite: 10-15 µm long, pear- or lemon-shaped with 3 anterior flagella, a round anterior nucleus, a short, sharply pointed tail and a large cytostomal groove.  Cyst: 6-9 µm, lemon-shaped.

Etiology:  Spironucleus muris is a flagellated protozoan.

Incidence:  The incidence of infection is low in conventional gerbil colonies.

Transmission:  Ingestion of infective cysts passed in fecal material is the primary mode of transmission.

Distribution:  Found primarily in the crypts of the duodenum and pyloric glands. In young animals, luminal protozoa are more numerous.

Clinical Signs:  Clinical signs are not usually observed.

Diagnosis:  Direct smears of small intestinal contents reveal fast darting protozoa.  Fecal PCR may also be used.

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Diagnostic Morphology:  Trophozoite: 7- 9 x 2- 3 µm, piriform (teardrop)-shaped or carrot-shaped, with 6 anterior flagella, 2 posterior flagella, 2 anterior nuclei and 2 separate axostyles.

 

Etiology:  Giardia muris is a one-celled eukarytic organism.

Incidence:  Infection with Giardia muris is rare.

Transmission:  Fecal-oral transmission via ingestion of infective cysts.

Distribution:  Giardia muris is found in the anterior small intestine.

Clinical signs:  Clinical signs are not usually observed. These protozoa may proliferate in diarrheic states, however their role as contributors to disease is poorly defined.

Diagnosis:

Antemortem: Fecal PCR can be used. Wet mounts of fresh fecal material or use of sucrose gradient may reveal cyst forms (difficult).

Postmortem: Wet mounts of intestinal contents may reveal slow-moving flagellated protozoa with a “falling leaf” rolling motility. Histopathologic examination may also be used to diagnose Giardia species infection.

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Diagnostic morphology:  Broad, piriform trophozoite with 2 anterior nuclei that when stained with weak iodine solution gives the appearance of a “monkey face.” There are eight caudally directed flagella.